Sodium Hyaluronate

Sodium Hyaluronate
02.12.2021
100

Sodium Hyaluronate:

Hyaluronic acid (HA) is the main GAG present in the amorphous interstitial matrix of connective tissue.

GAGs (glycosaminoglycans) are polysaccharide molecules consisting of repeating mono- or disaccharide units; hyaluronic acid is a polyglucodimer consisting of N-acetyl glucosamine and glucuronic acid. HA is the only GAG whose molecule does not include sulphate groups, and the only one with an unbranched linear structure. The other GAGs present in the amorphous matrix of connective tissue, and components of other connective tissue structures such as tendons and cartilage, are chondroitin sulphate, keratan sulphate, heparan sulphate, dermatan sulphate and heparin. HA performs crucial hydrating functions in ECM, promoting cell mobility, exchange of nutrients and soluble protein factors, and modulating the biochemical phenomena of regeneration and organisation of the fibro-connective tissue matrix.

It is contained in all the connective tissue, often associated with proteins, and in particular it is found in the synovial fluid.

Hyaluronic acid plays a fundamental role in the resistance of tissues and joints to compressive forces; it is also produced in large quantities during wound repair processes.

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